Will Ferrell
Maxime (voice)
Megamind (voice)
Lord Business / President Business / The Man Upstairs
Frank Ricard
Lonnie 'The Hawk' Hawkins
Brad Whitaker
Mugatu
Jacobim Mugatu
President Business / Dad
Detective Allen Gamble
Reggie (voice)
Brennan Huff
Ron Burgundy
James King
Chazz Michael Michaels
Ted (Man with the Yellow Hat) (voice)
Phil Weston
Dr. Rick Marshall
Present
Ron Burgundy
Federal Wildlife Marshal Willenholly
Franz Liebkind
Cam Brady
Sherlock Holmes
Jack Wyatt
Harold Crick
Jackie Moon
Ron Burgundy
Scott Johansen/The Butcher
Lars Erickssong
Megamind (voice)