Ryan Reynolds
Wade Wilson / Deadpool / Nicepool
Wade Wilson / Deadpool
Andrew Paxton
Wade Wilson / Deadpool / Juggernaut (voice)
Guy (voice)
Guy (voice)
Detective Pikachu (voice)
Nolan Booth
Big Adam
Hal Jordan / Green Lantern
Michael Bryce
Hannibal King
Michael Bryce
Young Damian
Mitch Planko
Richard Messner
Matt Weston
Wade Wilson / Deadpool / Juggernaut (voice)
Nick Walker
Bill Pope
Van Wilder
Paul Conroy
Will Hayes
George Lutz
Male Nurse
Chris Brander
Clint Briggs
Randol Schoenberg
Jerry Hickfang / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice)
Mike Connell
Gary / Gavin / Gabriel
Curtis
Frank Allen